Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection
نویسندگان
چکیده
منابع مشابه
Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection.
Macrophages are essential for systemic iron recycling, and also control iron availability to pathogens. Iron metabolism in mammalian cells is orchestrated posttranscriptionally by iron-regulatory proteins (IRP)-1 and -2. Here, we generated mice with selective and combined ablation of both IRPs in macrophages to investigate the role of IRPs in controlling iron availability. These animals are hyp...
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Nutritional iron deficiency in mice attenuated Salmonella typhimurium infection compared with both iron-substituted littermates and normal diet control animals.
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Exposure to bacteria, fungi, and protozoa is an inescapable part of life from the moment that we are born until we die. Our contact with many of these microorganisms is very brief, whereas others stay behind and establish a more stable relationship. These organisms become part of our normal flora and are found, among other places, on the skin, in the mouth, and in the gastrointestinal tract. Ty...
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The capacity of readily exchanging electrons makes iron not only essential for fundamental cell functions, but also a potential catalyst for chemical reactions involving free-radical formation and subsequent oxidative stress and cell damage. Cellular iron levels are therefore carefully regulated in order to maintain an adequate substrate while also minimizing the pool of potentially toxic 'free...
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Iron deficiency is a nutritional problem in plants and reduces crop productivity, quality and yield. With the goal of improving the iron (Fe) storage properties of plants, we have investigated the function of three Arabidopsis proteins with homology to Vacuolar Iron Transporter1 (AtVIT1). Heterologous expression of Vacuolar Iron Transporter-Like1 (AtVTL1; At1g21140), AtVTL2 (At1g76800) or AtVTL...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2015
ISSN: 1931-3128
DOI: 10.1016/j.chom.2015.06.017